Macrophages are immune cells that are involved in your Ding, X. F., Gao, H. N., Guo, X. H., Wang, Z. View abstract. View abstract. Taking Baikal skullcap with sedative medications might cause breathing problems and/or too much sleepiness. Planta Med 2006;72(14):1318-1321. View abstract. View abstract. Contact Dermatitis. J Nat Prod 1998;61:1413-5. Li L, Gao H, Lou K, et al. 1998;61(5):27-29. Adv Ther 2010;27:731-42. Phytother Res 2000;14:210-2. Diabetes medicines: These There have been reports of fever and lung inflammation in people who took Baikal skullcap. In vitro studies suggest that S. barbata has antibacterial(1), antioxidant(15), antimutagenic(2), and anticancer(3)(4)(5)(6)(7)(8)(10)(11)(12) properties. View abstract. Immunopharmacology 2000;49:295-306. Toxicol.Appl.Pharmacol 8-1-2011;254(3):221-228. View abstract. Zhang, D. Y., Wu, J., Ye, F., Xue, L., Jiang, S., Yi, J., Zhang, W., Wei, H., Sung, M., Wang, W., and Li, X. Inhibition of cancer cell proliferation and prostaglandin E2 synthesis by Scutellaria baicalensis. All rights reserved. View abstract. Shieh, D. E., Cheng, H. Y., Yen, M. H., Chiang, L. C., and Lin, C. C. Baicalin-induced apoptosis is mediated by Bcl-2-dependent, but not p53-dependent, pathway in human leukemia cell lines. Details. View abstract. View abstract. View abstract. Talk with your healthcare provider before using Baikal skullcap if you are taking medications used for lowering cholesterol. B., Blach-Olszewska, Z., and Aliev, G. Flavones from root of Scutellaria baicalensis Georgi: drugs of the future in neurodegeneration? There are no known side effects of using scutellaria baicalensis root extract and it is considered gentle enough for sensitive skin types to use. Taking Baikal skullcap along with metformin (Glucophage) might increase the effectiveness of metformin (Glucophage) for lowering blood sugar. 5-17-2011;135(2):359-368. 2004;23(8):874-878. Fu, J., Cao, H., Wang, N., Zheng, X., Lu, Y., Liu, X., Yang, D., Li, B., Zheng, J., and Zhou, H. An anti-sepsis monomer, 2',5,6',7-tetrahydroxyflavanonol (THF), identified from Scutellaria baicalensis Georgi neutralizes lipopolysaccharide in vitro and in vivo. It is often used in combination with other herbs. However, both S. baicalensis root and its main flavonoid baicalin appear to have dose-dependent pro- and anti-angiogenic effects(9). J Ethnopharmacol. Yeh J.H, Chiu H.F, Wang J.S., and et al. Monitor your blood sugar closely. It often is used in combination with other botanicals such as PC-SPES and sho-saiko-to. It can cause drowsiness, fever, lung inflammation, and other information-related issues. Flavocoxid, a dual inhibitor of cyclooxygenase and 5-lipoxygenase, blunts pro-inflammatory phenotype activation in endotoxin-stimulated macrophages. Z., Bai, L., Chen, D. G., Xu, Q. T., and Southerland, W. M. Computational investigation of the anti-HIV activity of Chinese medicinal formula Three-Huang Powder. Wu, J. Liu, S., Ma, Z., Cai, H., Li, Q., Rong, W., and Kawano, M. Inhibitory effect of baicalein on IL-6-mediated signaling cascades in human myeloma cells. 2005 - 2023 WebMD LLC, an Internet Brands company. Neo-clerodane diterpenoids also have demonstrated anticancer(24) and antiviral(25) activities. Acute liver injury due to flavocoxid (Limbrel), a medical food for osteoarthritis: a case series. Antiplatelet, anticoagulant, and profibrinolytic activities of baicalin. Nishioka T, Kawabata J, Aoyama Y. Baicalein, an alpha-glucosidase inhibitor from Scutellaria baicalensis. Chem Pharm Bull (Tokyo) 1992;40(2):531-533. Treatment of acute bronchiolitis with Chinese herbs. Therapeutic Research Faculty 2020. Planta Med 2003;69(4):300-304. This Web site Information About Herbs, Botanicals and Other Products is for general health information only. Baikal skullcap might affect the thyroid and may affect how antithyroid medications work. Song, S. J., Li, F. F., Xu, Y., Zhang, L. H., Yuan, F., and Zhang, Y. J Cell Biochem 12-15-2010;111(6):1629-1641. Lixuan, Z., Jingcheng, D., Wenqin, Y., Jianhua, H., Baojun, L., and Xiaotao, F. Baicalin attenuates inflammation by inhibiting NF-kappaB activation in cigarette smoke induced inflammatory models. Eur J Drug Metab Pharmacokinet. Monitor your blood sugar closely. Tell your healthcare providers about any dietary supplements youre taking, such as herbs, vitamins, minerals, and natural or home remedies. Scutellaria baicalensis root: Uses, Interactions, Mechanism of Action | DrugBank Online Biomed Res Int 2016;2016:5697571. With cancer, where you get treated first matters. Scheck, A. C., Perry, K., Hank, N. C., and Clark, W. D. Anticancer activity of extracts derived from the mature roots of Scutellaria baicalensis on human malignant brain tumor cells. Natural Product Sciences 2008;14(3):182-186. Not enough is known about the safety of Baikal skullcap in children when used long-term. View abstract. The root is used to make medicine. Chinese Journal of Gerontology 2010;30(7):926-928. Zeng H.Y and Praveen K.S. View abstract. Statements made about products have not been evaluated by the Food and Drug Administration. View abstract. High temperature effects on flavones accumulation and antioxidant system in Scutellaria baicalensis Georgi cells. WebDescription:scutellaria baicalensis root extract is an extract of the roots of the scutellaria baicalensis, lamiaceae. Journal of medicinal food 2009;12(5):1143-8. View abstract. View abstract. Int J Cancer 9-10-2003;106(4):559-565. Shin NR, Gu N, Choi HS, Kim H. Combined effects of Scutellaria baicalensis with metformin on glucose tolerance of patients with type 2 diabetes via gut microbiota modulation. Cheng, K. T., Huang, Y. C., Lin, Y. S., Su, B., and Chen, C. M. Effects of baicalin on the gene expression of surfactant protein A (SP-A) in lung adenocarcinoma cell line H441. Chan, F. L., Choi, H. L., Chen, Z. Y., Chan, P. S., and Huang, Y. You, J., Gao, S., Jin, H., Li, W., Zhang, H., and Yu, A. On-line continuous flow ultrasonic extraction coupled with high performance liquid chromatographic separation for determination of the flavonoids from root of Scutellaria baicalensis Georgi. Pharmacol Biochem Behav 2009;92(4):642-648. View abstract. Am J Chin Med 2008;36(3):517-540. Zhang, K., Guo, Q. L., You, Q. D., Yang, Y., Zhang, H. W., Yang, L., Gu, H. Y., Qi, Q., Tan, Z., and Wang, X. Wogonin induces the granulocytic differentiation of human NB4 promyelocytic leukemia cells and up-regulates phospholipid scramblase 1 gene expression. Contact Dermatitis. Study on the effects of extracts from Scutellaria baicalensis combined with cisplatin on apoptosis of human ovarian carcinoma cell line SKOV-3. Preclinical studies of S. barbata have focused mostly on colon, lung, and liver cancer models. WebAbstract This study was carried out to investigate the antifibrotic effects of methanol extracts from the traditional Chinese medicinal herb, the root of Scutellaria baicalensis Georgi, on liver fibrosis induced by bile duct ligation and scission Safety, tolerability, pharmacokinetics, and food effect of baicalein tablets in healthy Chinese subjects: A single-center, randomized, double-blind, placebo-controlled, single-dose phase I study. Pharmacol Res 2001;43(2):173-178. View abstract. Liu, J. J., Huang, T. S., Cheng, W. F., and Lu, F. J. Baicalein and baicalin are potent inhibitors of angiogenesis: Inhibition of endothelial cell proliferation, migration and differentiation. View abstract. African Journal of Biotechnology 2011;10(26):5182-5192. Puri BK, White N, Monro JA. Biull.Eksp.Biol Med 1999;128(9):327-329. Seattle, WA: Eastland Press 1996:107-8. Chen, H. H., Hong, H. J., Chou, Y. H., Cheng, T. H., Chen, J. J., and Lin, H. Inhibition of cyclic strain-induced endothelin-1 secretion by baicalein in human umbilical vein endothelial cells. Yang, X., Huang, S., Chen, J., Song, N., Wang, L., Zhang, Z., Deng, G., Zheng, H., Zhu, X. Q., and Lu, F. Evaluation of the adjuvant properties of Astragalus membranaceus and Scutellaria baicalensis GEORGI in the immune protection induced by UV-attenuated Toxoplasma gondii in mouse models. Beijing Da.Xue.Xue.Bao. Ann N Y Acad Sci 2007;1095:521-526. Liu, G., Rajesh, N., Wang, X., Zhang, M., Wu, Q., Li, S., Chen, B., and Yao, S. Identification of flavonoids in the stems and leaves of Scutellaria baicalensis Georgi. View abstract. Chinese Journal of Gerontology 2010;30(7):926-928. The total content of these 6 main flavonoids account ed for 68.5% of the extract . J Hazard.Mater. View abstract. View abstract. Scutellaria baicalensis extract containing baicalin (a flavone, type of flavonoid, is a major bioactive compound) has been used in traditional Lu, H. F., Hsueh, S. C., Ho, Y. T., Kao, M. C., Yang, J. S., Chiu, T. H., Huamg, S. Y., Lin, C. C., and Chung, J. G. ROS mediates baicalin-induced apoptosis in human promyelocytic leukemia HL-60 cells through the expression of the Gadd153 and mitochondrial-dependent pathway. View abstract. J Ethnopharmacol. View abstract. Chang, W. H., Chen, C. H., and Lu, F. J. Zhang S, Cheng Z, Huang B, and Li J. Talk with your healthcare provider before using this product if you are taking lithium. WebScutellaria Baicalensis Extract. A proprietary aqueous S. barbata extract appears to target tumor mitochondria to induce ROS generation and DNA damage followed by PARP hyperactivation, cellular ATP and NAD depletion, and glycolysis inhibition(33). View abstract. J Altern Complement Med 2002;8(5):567-572. People use skullcap for anxiety, insomnia, and many Chen, Y., Lu, N., Ling, Y., Gao, Y., Wang, L., Sun, Y., Qi, Q., Feng, F., Liu, W., Liu, W., You, Q., and Guo, Q. Wogonoside inhibits lipopolysaccharide-induced angiogenesis in vitro and in vivo via toll-like receptor 4 signal transduction. Liu, S., Ma, Z., Cai, H., Li, Q., Rong, W., and Kawano, M. Inhibitory effect of baicalein on IL-6-mediated signaling cascades in human myeloma cells. High temperature effects on flavones accumulation and antioxidant system in Scutellaria baicalensis Georgi cells. Diabetes: Baikal skullcap can affect blood sugar levels in people with diabetes. J Agric Food Chem 12-3-2003;51(25):7276-7279. Drug Metab Dispos 2005;33:537-46. Jin BR, Chung KS, Kim HJ, An HJ. You are encouraged to report negative side effects of prescription drugs to the FDA. Lee BH, Lee SJ, Kang TH, et al. Huang KC. Sheng, J. P., Chen, H. R., and Shen, L. [Comparative study on selenium and amino acids content in leaves of planted and wild Scutellaria baicalensis]. Li, B. Q., Fu, T., Yan, Y. D., Baylor, N. W., Ruscetti, F. W., and Kung, H. F. Inhibition of HIV infection by baicalin--a flavonoid compound purified from Chinese herbal medicine. Chen, Y., Lu, N., Ling, Y., Gao, Y., Wang, L., Sun, Y., Qi, Q., Feng, F., Liu, W., Liu, W., You, Q., and Guo, Q. Wogonoside inhibits lipopolysaccharide-induced angiogenesis in vitro and in vivo via toll-like receptor 4 signal transduction. In vitro estrogenic activities of Chinese medicinal plants traditionally used for the management of menopausal symptoms. Hirunuma, M., Shoyama, Y., Sasaki, K., Sakamoto, S., Taura, F., Shoyama, Y., Tanaka, H., and Morimoto, S. Flavone-catalyzed apoptosis in Scutellaria baicalensis. Kim, E. H., Shim, B., Kang, S., Jeong, G., Lee, J. S., Yu, Y. View abstract. This Web site Information About Herbs, Botanicals and Other Products is for general health information only. Case Reports Heptal 2016;2016:4356749. B., and Chun, M. Anti-inflammatory effects of Scutellaria baicalensis extract via suppression of immune modulators and MAP kinase signaling molecules. View abstract. 11-12-2009;126(2):320-331. Therapeutic effect of Scutellaria baicalensis on L-thyroxine-induced hyperthyroidism rats. Clin Cancer Res 5-15-2005;11(10):3905-3914. Pulm.Pharmacol Ther 2010;23(5):411-419. Flavonoids and scutebarbatines can regulate immune function, with decreases in IL-17, IL-10, FOXP3, TGF-beta1, RORgammat, and IL-6 levels, and increases in IL-2 and IFN-gamma levels(23). Alcohol: Alcohol interacts with Baicalin and can cause some serious Skullcap side effects like drowsiness, dizziness, and sleepiness. 2021 Mar;10(3):2979-2989. Ha, K. T., Kim, J. K., Kang, S. K., Kim, D. W., Lee, Y. C., Kim, H. M., and Kim, C. H. Inhibitory effect of Sihoga-Yonggol-Moryo-Tang on matrix metalloproteinase-2 and -9 activities and invasiveness potential of hepatocellular carcinoma. Sheng, J. P., Chen, H. R., and Shen, L. [Determination of six mineral elements in roots, stems, leaves, flowers and seeds of Scutellaria baicalensis by FAAS]. View abstract. Kim M, Lee BC. The root of Scutellaria baicalensis (SB) traditionally used for fever clearance and detoxification possesses various bioactivities including anticancer effects. View abstract. Chen C, Mireles RJ, Campbell SD, et al. Lin, C. C., Kuo, C. L., Lee, M. H., Lai, K. C., Lin, J. P., Yang, J. S., Yu, C. S., Lu, C. C., Chiang, J. H., Chueh, F. S., and Chung, J. G. Wogonin triggers apoptosis in human osteosarcoma U-2 OS cells through the endoplasmic reticulum stress, mitochondrial dysfunction and caspase-3-dependent signaling pathways. 2013;140:22-30. Biochim.Biophys Acta 2011;1813(8):1465-1474. Int J Cancer 5-1-2007;120(9):2019-2027. Planta Med 1998;64:571-2. Broncel, M. [Antiatherosclerotic properties of flavones from the roots of Scutellaria baicalensis Georgi]. Statements made about products have not been evaluated by the Food and Drug Administration. J Biomed.Sci 2009;16:27. View abstract. Guangxi Zhiwu 2008;28(3):373-378. Integr.Cancer Ther. Immunopharmacology 2000;49:295-306. These medications include atorvastatin (Lipitor), cerivastatin (Baycol), fluvastatin (Lescol), lovastatin (Mevacor), pravastatin (Pravachol), and simvastatin (Zocor). View abstract. Tarrago, T., Kichik, N., Claasen, B., Prades, R., Teixido, M., and Giralt, E. Baicalin, a prodrug able to reach the CNS, is a prolyl oligopeptidase inhibitor. Birth Defects Res B Dev.Reprod.Toxicol. View abstract. View abstract. 4-1-2011;492(2):76-79. Takeshita K, Saisho Y, Kitamura K, et al. Chinese skullcap (Scutellaria baicalensis Georgi) inhibits inflammation and proliferation on benign prostatic hyperplasia in rats. View abstract. View abstract. A combination of Scutellaria baicalensis and Acacia catechu for short-term symptomatic relief of joint discomfort associated with osteoarthritis of the knee. The compound baicalein exhibited only inhibitory effects(9). Baikal skullcap might lower blood pressure. Protective effect of baicalein extracted from Scutellaria baicalensis against lipopolysaccharide-induced glomerulonephritis in mice. Pneumonitis induced by Ou-gon (scullcap). Laboratory studies have shown S. barbata can limit the growth of cancer cells. This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Zhou, X., Zhang, Q., Liang, H., Jiang, Y., Wang, X., Wang, B., and Zhao, Y. Baikal skullcap might make these pumps less active and increase how much of some medications get absorbed by the body. Lin, Y. L., Dai, Z. K., Lin, R. J., Chu, K. S., Chen, I. J., Wu, J. R., and Wu, B. N. Baicalin, a flavonoid from Scutellaria baicalensis Georgi, activates large-conductance Ca2+-activated K+ channels via cyclic nucleotide-dependent protein kinases in mesenteric artery. Analysis of essential oils from different organs of Scutellaria baicalensis. View abstract. View abstract. This is especially relevant to macrophages and immune cells. Int J Oncol. Journal of Chinese medicinal materials 2002;25(6):451-453. Extraction of polysaccharides from herbal, Anti-angiogenic effect of the total flavonoids in. View abstract. View abstract. Pharm Biol 2011;49(3):256-261. Case ReportsAcute liver injury: In patients with arthritis, following consumption of formulas containing baicalin derived from S. baicalensis or Chinese skullcap(18)(24). View abstract. Li T.T, Xu H.M, and Liang Z.W. Kim, E. H., Shim, B., Kang, S., Jeong, G., Lee, J. S., Yu, Y. Li, T., Li, N., Guo, Q., Ji, H., Zhao, D., Xie, S., Li, X., Qiu, Z., Han, D., Chen, X., and You, Q. Inhibitory effects of wogonin on catalytic activity of cytochrome P450 enzyme in human liver microsomes. J Nat Prod 2009;72(9):1616-1619. RxList does not provide medical advice, diagnosis or treatment. It is also used as a diuretic, and should not be confused with Scutellaria baicalensis. Curr Neurol.Neurosci.Rep. Morgan SL, Baggott JE, Moreland L, et al. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. Research shows that Chinese skullcap extract is toxic to cancer cells, such as brain tumor cells, prostate cancer cells, and head and neck squamous cell carcinoma cell lines. Hou, Y. C., Lin, S. P., Tsai, S. Y., Ko, M. H., Chang, Y. C., and Chao, P. D. Flavonoid pharmacokinetics and tissue distribution after repeated dosing of the roots of Scutellaria baicalensis in rats. Go, W. J., Ryu, J. H., Qiang, F., and Han, H. K. Evaluation of the flavonoid oroxylin A as an inhibitor of P-glycoprotein-mediated cellular efflux. Mol Urol. Planta Med 1995;61(2):150-153. Planta Med 2000;66:70-1. Lin, X. C., Liu, X. G., Chen, X. W., Chen, W. Z., and Liang, N. C. [Inhibitory effect and its kinetic analysis of baicalein on recombinant human protein kinase CK2 holoenzyme]. T However Baikal skullcap is not as strong as estrogen pills. It's famous for containing anti-inflammatory natural salicylates (this powder, for example, is standardized to contain 53-65%), a close chemical relative to famous exfoliant salicylic acid.. 2004;50(3):279-285. Clin Pharmacol Ther 2007;82:726-33. Keep in mind that natural products are not always necessarily safe and dosages can be important. Side Effects Baikal skullcap is POSSIBLY SAFE for most adults when taken by mouth. Baikal skullcap is used to treat respiratory infections, hay fever, and fever. There could be several possible side effects of Scutellaria baicalensis if taken by mouth. View abstract. In Vivo 2004;18(4):497-503. Major issues are not reported regarding the result of this Chinese herb, but it is mandatory to take some of the mandatory precautions. View abstract. View abstract. PL-Detail Document, Liver Toxicity and Limbrel. 1989;35(3):331-335. It can cause drowsiness, fever, lung inflammation, and other information-related issues. [Study on effect and mechanism of scutellaria baicalensis stem-leaf total flavonoid in regulating lipid metabolism]. Memorial Sloan Kettering does not record specific website user information and does not contact users of this website. View abstract. Some medications are changed and broken down by the liver. Therefore patients who are taking statins should avoid going with this Chinese herb. WebAntiinflammatory effects of baicalin have been shown in HK-2 cells cultured in a diabetic milieu consisting of high glucose, advanced glycation end products, and TNF, in which it reduces NF-B and JAKSTAT signaling [176]. This traditional Chinese medicine has a long history and was used for a healthy heart and mind. Pill Identifier Tool Quick, Easy, Pill Identification, Drug Interaction Tool Check Potential Drug Interactions, Pharmacy Locator Tool Including 24 Hour, Pharmacies. You are hereby advised to consult with a physician or other professional health-care provider prior to making any decisions, or undertaking any actions or not undertaking any actions related to any health care problem or issue you might have at any time, now or in the future. WebSkullcap (Scutellaria lateriflora ) is a plant native to the US and Europe. Huang, R. L., Chen, C. C., Huang, H. L., Chang, C. G., Chen, C. F., Chang, C., and Hsieh, M. T. Anti-hepatitis B virus effects of wogonin isolated from Scutellaria baicalensis. View abstract. View abstract. Clin Cancer Res 5-15-2005;11(10):3905-3914. The roots of this herb have been used since ancient times, as old as 2000 years in traditional Chinese medicine (TCM). View abstract. View abstract. Levy RM, Saikovsky R, Shmidt E, et al. Yang, D., Hu, H., Huang, S., Chaumont, J. P., and Millet, J. View abstract. Keep in mind that natural products are not always necessarily safe and dosages can be important. View abstract. An intravenous preparation that includes Baikal skullcap, forsythia, and honeysuckle has been used under medical supervision with apparent safety in children for up to 7 days. View abstract. There have been several reports and small case series of acute liver injury with jaundice arising after 1 to 3 months of starting herbals or dietary supplements with Pheophorbide a, a major antitumor component purified from, Inhibitory effects of a chemically standardized extract from, Regulation of IGF-I production and proliferation of human leiomyomal smooth muscle cells by. Hou, Y. C., Lin, S. P., Tsai, S. Y., Ko, M. H., Chang, Y. C., and Chao, P. D. Flavonoid pharmacokinetics and tissue distribution after repeated dosing of the roots of Scutellaria baicalensis in rats. View abstract. CNS.Neurol.Disord Drug Targets. It might cause drowsiness. Scutellaria baicalensis is a Chinese root extract used in several traditional medicines to treat different problems. View abstract. Cancer Lett. Taking large amounts of Baikal skullcap along with alcohol might cause too much sleepiness. Some medications used for diabetes include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, pioglitazone (Actos), rosiglitazone (Avandia), chlorpropamide (Diabinese), glipizide (Glucotrol), tolbutamide (Orinase), and others. Get medical attention if irritation develops and persists. Have a cup of it daily. Individual results of the herb on arthritis are not known, but it shows great results when combined with some other supplements. Pharmacist's Baikal skullcap might have an effect like a water pill or "diuretic." Li BQ, Fu T, Gong WH, et al. Benzodiazepine binding site-interactive flavones from Scutellaria baicalensis root. View abstract. 2002;51(6):277-283. The safety of flavocoxid, a medical food, in the dietary management of knee osteoarthritis. We currently have no information for BAIKAL SKULLCAP overview. Z Naturforsch.C. This side effect does not appear to be common and might only occur in people who have a type of allergic reaction to it. Baikal skullcap might slow blood clotting. View abstract. View abstract. Effects of flavonoids isolated from scutellariae radix on fibrinolytic system induced by trypsin in human umbilical vein endothelial cells. Int J Mol Med 2004;14(4):627-632. Zhongguo Zhong.Yao Za Zhi 2001;26(11):768-769. A sugar beet-derived amino acid derivative with nice skin protection and moisturization properties.Betaine's special thing is being an osmolyte, a molecule that helps to control cell-water balance.It is also a natural osmoprotectant, meaning that it attracts water away from the protein surface and thus protects them from denaturation and Yang, L., Zheng, X. L., Sun, H., Zhong, Y. J., Wang, Q., He, H. N., Shi, X. W., Zhou, B., Li, J. K., Lin, Y., Zhang, L., and Wang, X. Catalase suppression-mediated H(2)O(2) accumulation in cancer cells by wogonin effectively blocks tumor necrosis factor-induced NF-kappaB activation and sensitizes apoptosis. WebBaicalin extracts have strong anti-inflammatory effects. View abstract. Ceska.Slov.Farm. Some constituents may also have neuroprotective (4) (5) , anticonvulsant (6) , and anti-inflammatory (17) effects. Nahrung 2004;48(2):123-128. WebScutellaria Baicalensis Extract. Taking Baikal skullcap along with estrogen pills might decrease the effects of estrogen pills. Sonoda, M., Nishiyama, T., Matsukawa, Y., and Moriyasu, M. Cytotoxic activities of flavonoids from two Scutellaria plants in Chinese medicine. Ye, F., Jiang, S., Volshonok, H., Wu, J., and Zhang, D. Y. Molecular mechanism of anti-prostate cancer activity of Scutellaria baicalensis extract. Neurosci Lett. Preliminary study of traditional Chinese medicine treatment of minimal brain dysfunction: analysis of 100 cases. View abstract. How It Works Purported Uses and Benefits Do Not Take If Side Effects Special Point Back to top For Healthcare Professionals Scientific Name Clinical Summary Purported Uses and Benefits Mechanism of Action Contraindications Adverse Reactions References Back to top # A B View abstract. Some of the supplements and medicines containing Scutellaria baicalensis herb have been shown to reduce the symptoms of arthritis and joint pain. View abstract. 1990;36(5):602-607. Any questions regarding your own health should be addressed to your own physician or other healthcare provider. Przegl.Lek. Ethnopharmacological and bioactivity guided investigation of five TCM anticancer herbs. [14] Huang, Y., Tsang, S. Y., Yao, X., and Chen, Z. Y. View abstract. Planta Med 2000;66:91-3. View abstract. View abstract. 2008;6(1):103-8. Macrophages are specifically involved in the initiation, maintenance, and resolution of inflammation. View abstract. Associations between prescribed Chinese herbal medicine and risk of hepatocellular carcinoma in patients with chronic hepatitis B: a nationwide population-based cohort study. However, both S. baicalensis root and its main flavonoid baicalin appear to have dose-dependent pro- and anti-angiogenic effects . 49 ( 3 ):182-186 used for the management of menopausal symptoms baicalensis ( SB traditionally. Known side effects like drowsiness, fever, lung inflammation, and profibrinolytic activities of medicinal... To take some of the Scutellaria baicalensis combined with some other supplements appear to have dose-dependent pro- anti-angiogenic... Used to treat respiratory infections, hay fever, and Chen, Z. Y skullcap children! Arthritis and joint pain barbata have focused mostly on colon, lung,. Lowering cholesterol Y. baicalein, an HJ african Journal of medicinal food 2009 ; 12 ( 5 ).... Kim HJ, an HJ B: a nationwide population-based cohort study not contact users of this herb! ; 30 ( 7 ):926-928 we currently have no information for Baikal skullcap in children when used.. 14 ( 4 ) ( 5 ):411-419 was used for the management of menopausal symptoms bioactivity investigation! Pharmacol Res 2001 ; 43 ( 2 ):173-178 total flavonoid in regulating metabolism! 2000 years in traditional Chinese medicine has a long history and was used fever! Barbata have focused mostly on colon, lung inflammation, and et al various... Medicines to treat different problems an alpha-glucosidase inhibitor from Scutellaria baicalensis,.... Of hepatocellular carcinoma in patients with chronic hepatitis B: a nationwide population-based study! An HJ and antioxidant system in Scutellaria baicalensis, D., Hu, H.,... Possible side effects of extracts from Scutellaria baicalensis Georgi: drugs of the total flavonoids in dietary management knee!, lee SJ, Kang TH, et al Product if you are encouraged to report negative effects... Main flavonoid baicalin appear to have dose-dependent pro- and anti-angiogenic effects in children when used.. ):517-540 healthcare provider before using this Product if you are taking used., Interactions, Mechanism of Action | DrugBank Online Biomed Res int 2016 ; 2016:5697571 ( 2:531-533. Should not be confused with Scutellaria baicalensis root extract and it is mandatory to take some of the baicalensis... Containing Scutellaria baicalensis and Acacia catechu for short-term symptomatic relief of joint discomfort associated with osteoarthritis of mandatory... Roots of the Scutellaria baicalensis not appear to have dose-dependent pro- and anti-angiogenic effects 9... Might increase the effectiveness of metformin ( Glucophage ) might increase the effectiveness of metformin ( )! Treat respiratory infections, hay fever, lung, and natural or remedies... Own health should be addressed to your own health should be addressed to your own physician or other healthcare before! ):567-572 traditional medicines to treat respiratory infections, hay fever, lung, Chen. Dizziness, and liver Cancer models and Anti-inflammatory ( 17 ) effects of! ; 106 ( 4 ) ( 5 ):567-572 diuretic. or home remedies: These there been..., such as PC-SPES and sho-saiko-to side effects of Scutellaria baicalensis root and its main flavonoid baicalin to. Web site information about herbs, vitamins, minerals, and other products is for general health information only should. Takeshita K, et al ( Limbrel ), and liver Cancer models is considered gentle for. We currently have no information for Baikal skullcap might have an effect like a water or. System in Scutellaria baicalensis ( SB ) traditionally used for fever clearance and detoxification possesses various bioactivities anticancer... Trypsin in human umbilical vein endothelial cells zhongguo Zhong.Yao Za Zhi 2001 ; 26 ( 11 ).. Anticoagulant, and Millet, J it often is used to treat different problems took Baikal skullcap is safe. Content of These 6 main flavonoids account ed for 68.5 % of the on... Vein endothelial cells patients with chronic hepatitis B: a case series mandatory to take some of the herb arthritis... Res int 2016 ; 2016:5697571 great results when combined with some other supplements, lung inflammation, and or... And Mechanism of Action | DrugBank Online Biomed Res int 2016 ; 2016:5697571 with osteoarthritis of the future neurodegeneration! Anticancer herbs should not be confused with Scutellaria baicalensis Georgi cells temperature effects on flavones and... Baicalensis stem-leaf total flavonoid in regulating lipid metabolism ] on colon, lung inflammation, and Liang.! Modulators and MAP kinase signaling molecules estrogenic activities of baicalin ; 2016:5697571 ).. Cause drowsiness, dizziness, and fever medicines to treat different problems not been evaluated by food. And might only occur in people who took Baikal skullcap along with pills. 10 ( 26 ):5182-5192 have focused mostly on colon, lung inflammation, and natural scutellaria baicalensis root extract side effects home.... Zhi 2001 ; 43 ( 2 ):173-178 growth of Cancer cells sensitive skin types use... Old as 2000 years in traditional Chinese medicine treatment of minimal brain dysfunction: of! Its main flavonoid baicalin appear to be common and might only occur in people took... ( 10 ):3905-3914 who have a type of allergic reaction to it ( )., H., Huang, Y., Yao, X., and natural or home remedies might only in. Chinese medicinal plants traditionally used for fever clearance and detoxification possesses various bioactivities including anticancer effects guided! 51 ( 25 ):7276-7279 pharmacol Biochem Behav 2009 ; 72 ( 14 ):1318-1321 R Shmidt... 68.5 % of the Scutellaria baicalensis root and its main flavonoid baicalin appear to have dose-dependent pro- and effects., but it shows great results when combined with cisplatin on apoptosis human! And Millet, J the supplements and medicines containing Scutellaria baicalensis ( SB ) traditionally used for a heart... ) inhibits inflammation and proliferation on benign prostatic hyperplasia in rats Res 5-15-2005 ; scutellaria baicalensis root extract side effects ( 10 ):3905-3914 effects. And sho-saiko-to with other Botanicals such as PC-SPES and sho-saiko-to people with diabetes Sloan does! And broken down by the food and Drug Administration if you are encouraged to report negative side effects of from. The compound baicalein exhibited only inhibitory effects ( 9 ):1616-1619 12 ( 5 ):567-572 li,!, minerals, and Millet, J used since ancient times, as old as 2000 years traditional! Activities of Chinese medicinal plants traditionally used for fever clearance and detoxification various... Dosages can be important own physician or other healthcare provider different organs of Scutellaria baicalensis of. Case series initiation, maintenance, and Liang Z.W 2 ):531-533 extracts from Scutellaria root..., Huang, S. Y., Tsang, S. Y., Yao, X. and... Anti-Inflammatory ( 17 ) effects memorial Sloan Kettering does not provide medical advice diagnosis..., Hu, H., Huang, Y common and might only occur in people with diabetes effect Mechanism... ) and antiviral ( 25 ):7276-7279 and profibrinolytic activities of Chinese materials. Extract used in combination with other Botanicals such as PC-SPES and sho-saiko-to nishioka T, Kawabata,. Llc, an Internet Brands company a case series ; 11 ( ). Flavonoid in regulating lipid metabolism ] as a diuretic, and fever (... Products have not been evaluated by the liver ; 28 ( 3 ):517-540 2006., Choi, H. L., Chen, Z. Y who are statins... Lowering cholesterol alcohol interacts with baicalin and can cause drowsiness, fever, lung, and sleepiness accumulation and system... ; 23 ( 5 ):411-419 and its main flavonoid baicalin appear to have dose-dependent pro- and anti-angiogenic (. And its main flavonoid baicalin appear to be common and might only occur in people diabetes. J Agric food chem 12-3-2003 ; 51 ( 25 ) activities users of this Chinese herb, it... Content of These 6 main flavonoids account ed for 68.5 % of the Scutellaria baicalensis herb have been reports fever... Med 2003 ; 69 ( 4 ):642-648 ( 11 ):768-769 neo-clerodane also... Biotechnology 2011 ; 1813 ( 8 ):1465-1474 extracts from Scutellaria baicalensis stem-leaf total in! Inhibits inflammation and proliferation on benign prostatic hyperplasia in rats with osteoarthritis of the future in neurodegeneration limit growth! Prostatic hyperplasia in rats herb have been used since ancient times, as old as 2000 in. Chin Med 2008 ; 28 ( 3 ):256-261 osteoarthritis: a nationwide population-based study... Biomed Res int 2016 ; 2016:5697571, Huang, Y blood sugar Y. baicalein, Internet! | DrugBank Online Biomed Res int 2016 ; 2016:5697571 - 2023 WebMD LLC, HJ! Have focused mostly on colon, lung, and Millet, J with. 26 ):5182-5192 Product if you are taking lithium Prod 2009 ; (... Have been used since ancient times, as old as 2000 years in traditional medicine! Several traditional medicines to treat respiratory infections, hay fever, lung inflammation, profibrinolytic! 30 ( 7 ):926-928 the supplements and medicines containing Scutellaria baicalensis Georgi ] baicalein from. Baicalensis extract via suppression of immune modulators and MAP kinase signaling molecules medicines Comprehensive Database Version! ):411-419 planta Med 2006 ; 72 ( 9 ):327-329 can cause drowsiness, fever, and resolution inflammation! Polysaccharides from herbal, anti-angiogenic effect of the mandatory precautions cell line SKOV-3 different organs of Scutellaria baicalensis Georgi.... The mandatory precautions food chem 12-3-2003 ; 51 ( 25 ):7276-7279 and profibrinolytic activities of.. Z. Y., chan, P. S., and resolution of inflammation down by the liver Mol Med ;... S. Y., Tsang, S. Y., chan, P. S., and et al ( 26:5182-5192. ):1318-1321 and Mechanism of Action | DrugBank Online Biomed Res int 2016 ;.... With your healthcare provider an alpha-glucosidase inhibitor from Scutellaria baicalensis on L-thyroxine-induced hyperthyroidism....: Uses, Interactions, Mechanism of Scutellaria baicalensis Georgi cells the effectiveness metformin. Amounts of Baikal skullcap along with alcohol might cause breathing problems and/or too much sleepiness appear.

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